Structural Biology
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Nuclear Magnetic Resonance
Nexomics Biosciences has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis and structure determination.
NMR Data collection
500 MHz (cryoprobe, AutoSampler) Bruker
600 MHz (cryoprobe, AutoSampler) Bruker
700 MHz (cryoprobe, SampleJet) Bruker
800 MHz (cryoprobe, AutoSampler) Bruker
Probes include 19F, 31P and 1H, 2H, 13C,
15N-TR NMR
Non-Uniform Sampling (NUS) available
NMR Spectral analysis
Backbone assignments
Side-chain assignment
Protein-Protein, Protein-Nucleic Acid complex analysis
Dynamics, disorder, stability
Biosimilarity analysis
Structure Determination
Three-dimensional protein structure determination and quality assessment.
Ligand-protein complexes
Protein-protein complexes
X-ray Crystallography Structures
Nexomics Biosciences has extensive experience solving protein crystal structures, including protein-protein, and protein-nucleic acid complexes, using X-ray crystallography.
Crystal Screening
HTP screening (1536 conditions)
Standard kit-based screening
Crystal Optimization
Optimizing crystal hits to improve size and diffraction quality. Optimization measured using in-house light source.
Structure Determination
Three-dimensional protein structure calculation and quality assessment.
Cryogenic Electron Microscopy (cryo-EM) Structures
Nexomics Biosciences has capability solving protein cryo-EM structures, including protein-protein, and protein-nucleic acid complexes, using Cryogenic Electron Microscopy.
Feasibility
Feasibility &
Quality Assessment
Optimization
Optimizing to obtain high resolution data collection and generation of density map.
Structure Determination
Three-dimensional protein structure calculation and quality assessment.
Homology Modeling
Homology models are useful for pathway modeling, predictive protein-protein / protein-ligand interactive simulations and in general as a guide in the protein structure determination process. Nexomics Biosciences offers homology modeling using our proprietary modeling and structure validation software.